Because of refraction of the incoming wave in the radar-guided interceptors, the radome can cause large miss distance and even having a destabilizing effect on the guidance system. On the other hand, the radome imposes an unwanted feedback that is not similar to the conventional feedback loops, in which output must follow a desired control signal. In this paper, the destructive effect of radome in guidance loop stability and performance is analyzed at first. Then, proposing a virtual integrator operator, the problem is transformed to a conventional tracking control problem so that the performance indexes can be defined in control aspect. Regarding the parametric uncertainty of the radome slope, μ-synthesis approach is used to design a robust compensator. Simulation results and stability analysis show that the designed compensator improves the guidance system performance in the presence of the radome, while the stability is guaranteed.